Jacobsen Group Research

Synthetic Applications

Please visit our Reaction Gallery for a detailed overview of the methods developed in our lab and their applications.

Chiral Building Blocks

A wide variety of chiral intermediates that are otherwise difficult to access are now readily available as a direct result of our group’s efforts. This expansion of the “chiral pool” through practical asymmetric catalytic methods has a significant enabling impact on the way synthesis can be done. Chiral building blocks prepared using our methods have been applied to important targets by academic and industrial chemists throughout the world.

Complex Molecule Synthesis

In several cases, we have illustrated the utility of the reactions we have developed in the context of natural product synthesis. The hallmark of each of these total syntheses is the creative use of new asymmetric catalytic methodologies developed in our labs for the efficient and flexible construction of stereochemically complex targets.